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RESEARCH PRODUCT
An Approach to 2,4-Substituted Pyrazolo[1,5-a]pyridines and Pyrazolo[1,5-a]azepines by Ring-Closing Metathesis
Antonio Simón-fuentesAmparo AsensioRaquel RománMiguel A. MaestroJose Luis AcenaSantos Fusterosubject
chemistry.chemical_compoundRing-closing metathesischemistryBicyclic moleculeStereochemistryPeptidomimeticOrganic ChemistryPyridineEnantioselective synthesisPhysical and Theoretical ChemistryAzepineAmino acid residueMetathesisdescription
The ring-closing metathesis (RCM) reactions of dienylpyrazoles have been employed in the synthesis of pyrazolo[1,5-a]pyridine and pyrazolo[1,5-a]azepine derivatives. Based on this approach, the diastereoselective synthesis of potential peptidomimetics containing four amino acid residues with the second (i+1) and third (i+2) fragments having been substituted by bicyclic frameworks is described.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2013-09-19 | European Journal of Organic Chemistry |