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RESEARCH PRODUCT

Anti-HLA alloantibodies of the IgA isotype in re-transplant candidates part II: Correlation with graft survival

Malte ZiemannA. EnderChristian BachGottfried FischerStefan SchaubChristian SeidlD. ThammanichanondGideon HöngerFalko M. HeinemannAndrea DickMichael HallenslebenPeter A. HornNils LachmannMarie-luise ArnoldW. E. HitzlerJoannis MytilineosA. MühlbacherBernd M. Spriewald

subject

Male0301 basic medicinemedicine.medical_treatmentMedizinHistocompatibility Testing030230 surgery0302 clinical medicineAntibody SpecificityHLA AntigensIsoantibodiesMedicineChildGenetics (clinical)Aged 80 and overKidneybiologyGraft SurvivalGeneral MedicineMiddle AgedPrognosisIsotypemedicine.anatomical_structureChild PreschoolRetreatmentFemaleAntibodyAdultAdolescentImmunologyHuman leukocyte antigenYoung Adult03 medical and health sciencesGeneticsHumansMolecular BiologyAllelesDialysisAgedbusiness.industryOrgan TransplantationKidney TransplantationTransplant RecipientsImmunoglobulin ATransplantation030104 developmental biologyImmunoglobulin GImmunologybiology.proteinGraft survivalbusiness

description

We reported previously on the widespread occurrence of anti-HLA alloantibodies of the IgA isotype (anti-HLA IgA) in the sera of solid-organ re-transplantation (re-tx) candidates (Arnold et al., ). Specifically focussing on kidney re-tx patients, we now extended our earlier findings by examining the impact of the presence and donor specificity of anti-HLA IgA on graft survival. We observed frequent concurrence of anti-HLA IgA and anti-HLA IgG in 27% of our multicenter collective of 694 kidney re-tx patients. This subgroup displayed significantly reduced graft survival as evidenced by the median time to first dialysis after transplantation (TTD 77 months) compared to patients carrying either anti-HLA IgG or IgA (TTD 102 and 94 months, respectively). In addition, donor specificity of anti-HLA IgA had a significant negative impact on graft survival (TTD 74 months) in our study. Taken together, our data strongly indicate that presence of anti-HLA IgA, in particular in conjunction with anti-HLA-IgG, in sera of kidney re-tx patients is associated with negative transplantation outcome.

yearjournalcountryeditionlanguage
2017-10-30International Journal of Immunogenetics
https://doi.org/10.1111/iji.12363