Cxc group chemokines as biomarkersof non-small cell lung cancer

6533b870fe1ef96bd12cf5d6

RESEARCH PRODUCT

Cxc group chemokines as biomarkersof non-small cell lung cancer

subject

Ķirurģija Medicine Surgery Medicīna

description

CXC grupas hemokīnu un to receptoru saistība ar kanceroģenēzes procesu ir pierādīta vairākos pētījumos, tomēr CXC hemokīnu loma un klīniskā nozīme plaušu vēža gadījumā palikusi neskaidra. Pētījuma mērķis bija novērtēt CXC hemokīnu biomarķieru potenciālu un saistību ar audzēja un imūnsistēmas šūnām, audzēja mikrovides parametriem un klīniskajiem datiem no plaušu vēža pacientu grupām. Autors ir lietojis jaunu pieeju biomarķieru atklāšanai, lai apstiprinātu CXC hemokīnu iesaisti kanceroģenēzes procesā – konkrēti CXCL1, CXCL4, CXCL5, CXCL7, CXCL8, CXCL9, CXCL10 un CXCL11. CXCL9, CXCL10 un CXCL11 kombinācija parādīja spēcīgas biomarķieru paneļa īpašības, savukārt CXCL4 piemīt prognostiska biomarķiera īpašības, kas korelē ar audzēja angioģenēzes aktivitāti. Autors arī konstatēja, ka CXC hemokīnu līmenis un gradients korelē ar CXC receptoru ekspresiju un audzēju infiltrējošo imūno šūnu subpopulācijām

year	journal	country	edition	language
2017-01-01

https://dspace.lu.lv/dspace/handle/7/37283

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