6533b870fe1ef96bd12cf96d
RESEARCH PRODUCT
Quantitative online isolation of 68Ge from 68Ge/68Ga generator eluates for purification and immediate quality control of breakthrough
Frank RöschNatalia LoktionovaElisabeth Eppardsubject
RadiationChromatographyGenerator (computer programming)ElutionComputer scienceContext (language use)Isolation (database systems)description
The breakthrough of ⁶⁸Ge from a ⁶⁸Ge/⁶⁸Ga-generator is one of the most sensitive parameters in the context of the clinical application of ⁶⁸Ga-radiopharmaceuticals. The difficulty in its determination lies in the "spectroscopic invisibility" of ⁶⁸Ge within an excess of ⁶⁸Ga. The introduced method for determining the ⁶⁸Ge content of the ⁶⁸Ge/⁶⁸Ga-generator eluate involves the quantitative separation of ⁶⁸Ga from ⁶⁸Ge, using a cation-exchanger. The eluate contains ⁶⁸Ga free of ⁶⁸Ge, which can be determined immediately, i.e. prior to the application of the ⁶⁸Ga-radiopharmaceutical.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2013-12-01 | Applied Radiation and Isotopes |