Antigen-dependent competition shapes the local repertoire of tissue-resident memory CD8+ T cells.

6533b870fe1ef96bd12cfb7e

RESEARCH PRODUCT

Antigen-dependent competition shapes the local repertoire of tissue-resident memory CD8+ T cells.

Wolfgang Kastenmüller Wolfgang Kastenmüller Anne Fellenzer Dirk H. Busch Paul-albert König Sha Tao Georg Gasteiger Georg Gasteiger Georg Gasteiger Veit R. Buchholz Ronny Tao Thomas Korn Mathias Heikenwalder Christian Hessel Ingo Drexler Ingo Drexler Andreas Muschaweckh

subject

0301 basic medicine Immunology Receptors Antigen T-Cell Mice Transgenic Vaccinia virus Cell fate determination Biology CD8-Positive T-Lymphocytes Virus Article 312 03 medical and health sciences Mice 0302 clinical medicine Antigen 319 Vaccinia Immunology and Allergy Cytotoxic T cell Animals Antigens Viral Research Articles Cell growth Repertoire T-cell receptor Virology 030104 developmental biology CD8 030215 immunology Signal Transduction

description

Muschaweckh et al. show that antigen presentation in the skin regulates the generation of tissue-resident memory T (TRM) cells by orchestrating local competition of antiviral CD8+ T cells, revealing a mechanism to fine-tune the repertoire of regional pools of TRM cells.

year	journal	country	edition	language
2016-11-29

10.1084/jem.20160888 https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=50131

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