6533b870fe1ef96bd12cfd22
RESEARCH PRODUCT
Strain-specific development of the mossy fiber system in organotypic cultures of the mouse hippocampus
Wim E. CrusioB. HeimrichH. SchweglerP. RennerFlavio Kellersubject
Mossy fiber (hippocampus)Mice Inbred BALB CNeuronal PlasticityStrain (chemistry)General NeuroscienceHippocampusMice Inbred StrainsHippocampal formationBiologyHippocampusIn vitroCell biologyMice Inbred C57BLMiceSpecies SpecificityInbred strainMice Inbred DBAIn vivoAnimalsNeuroscienceCells CulturedExplant culturedescription
Abstract The postnatal development of the hippocampus of the inbred mice strains BALB/c, C57BL/6, and DBA/2 was studied in organotypic explant cultures using the roller-tube technique. In vivo, mice exhibit strain-specific mossy fiber distribution patterns. As a main result we found, that after cultivation of 3–4 weeks, similar strain-specific patterns became apparent in vitro, as visualized by a modified Timm staining. From this experiment we can conclude that a postnatal extrinsic influence cannot be the cause of the strain-specific hippocampal features.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1988-04-22 | Neuroscience Letters |