6533b870fe1ef96bd12cfd77
RESEARCH PRODUCT
(±)-alternarlactones A and B, two antiparasitic alternariol-like dimers from the fungus alternaria alternata P1210 isolated from the halophyte salicornia sp.
Till OpatzYi-ming ShiMarcel KaiserChristian RichterJose G. Maciá-vicenteHelge B. BodeStefan PuschHarald SchwalbeYan-ni Shisubject
Salicorniabiology010405 organic chemistryAntiparasiticmedicine.drug_classOrganic ChemistryAlternariolFungus010402 general chemistrybiology.organism_classification01 natural sciencesAlternaria alternata0104 chemical scienceschemistry.chemical_compoundchemistryHalophyteBotanymedicineLife Sciencedescription
Two new dimeric compounds of the alternariol class, (±)-alternarlactones A (1) and B (2), were isolated along with 11 known compounds from the fungus Alternaria alternata P1210. Their structures were elucidated with the assistance of long-range HSQMBC to address inadequate cross-peaks in HMBC that result from the highly dense quaternary carbons, as well as theoretical calculations. All isolated altenuisol derivatives were screened for their antiparasitic activities, which provide a preliminary structure-activity relationship of this class of compounds against neglected tropical diseases.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2019-08-14 |