Noradrenaline release from permeabilized synaptosomes is inhibited by the light chain of tetanus toxin

6533b870fe1ef96bd12d0506

RESEARCH PRODUCT

Noradrenaline release from permeabilized synaptosomes is inhibited by the light chain of tetanus toxin

B. Stecher Pierre N. E. De Graan Jacques J. H. Hens Ulrich Weller Manfred Gratzl W.h. Gispen

subject

Male Cell Membrane Permeability Clostridium tetani Biophysics Biology medicine.disease_cause Immunoglobulin light chain Biochemistry Exocytosis Exocytosis Geneeskunde Norepinephrine Structural Biology Permeabilization Genetics medicine Synaptosome Animals Neurotoxin Rats Wistar Streptolysin O Molecular Biology Synaptosome Toxin Cell Biology Rats Tetanus toxin Mechanism of action Biochemistry Streptolysin medicine.symptom Synaptosomes

description

AbstractNoradrenaline release from rat brain cortical synaptosomes permeabilized with streptolysin O can be triggered by μM concentrations of free Ca2+. This process was inhibited within minutes by tetanus toxin and its isolated light chain, but not by its heavy chain. The data demonstrate that the effect of tetanus toxin on NA release from purified synaptosomes is caused by the intraterminal action of its light chain.

year	journal	country	edition	language
1992-11-09	FEBS Letters

10.1016/0014-5793(92)80933-8 http://dx.doi.org/10.1016/0014-5793(92)80933-8

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