6533b870fe1ef96bd12d07b7
RESEARCH PRODUCT
Two New Retigerane-Type Sesterterpenoids from the Lichen Leprocaulon microscopicum
Marie Aleth Lacaille-duboisYves ChampavierMarie Martin-de-lassalleLengo MambuJose-albert ChuliaMarylène Chollet-kruglerMarion Millotsubject
RetigeranesChromatographySesterterpenesLichens010405 organic chemistryCentrifugal partition chromatographyChemistryOrganic ChemistryCarbon skeletonCentrifugal partition chromatography010402 general chemistryMass spectrometry01 natural sciencesBiochemistryCatalysis0104 chemical sciencesSesterterpenesInorganic ChemistryDrug DiscoveryLeprocaulon microscopicumLeprocaulon microscopicum[CHIM]Chemical SciencesPhysical and Theoretical ChemistryLichendescription
International audience; Two new sesterterpenes, 1 and 2, have been isolated from the lichen Leprocaulon microscopicum. In addition to classic chromatographic methods, a liquid-liquid chromatography technique, namely centrifugal partition chromatography (CPC) was applied for the purification of compound 2. The structures were determined by analyses of mass spectrometry and 1D- and 2D-NMR data. The relative configuration of the isolated compounds was assigned on the basis of 2D-NOESY experiments. The two compounds possess a rare pentacyclic carbon skeleton typical for lichen metabolism, and quite unusual in the vegetal kingdom.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-02-01 |