Vaccinium spp. ogu izspiedu ekstraktu pretiekaisuma īpašības

6533b870fe1ef96bd12d0984

RESEARCH PRODUCT

Vaccinium spp. ogu izspiedu ekstraktu pretiekaisuma īpašības

Marta Silavniece

subject

COX-1 ksantīna oksidāze Farmācija Vaccinium spp. izspiedu ekstrakti 5-LOX iekaisums

description

Ilgstošs iekaisums ir būtisks faktors hronisku slimību attīstībā, taču vēl joprojām nav pieejami pilnībā droši pretiekaisuma līdzekļi, tādēļ pasaulē pieaug interese par dabīgas izcelsmes savienojumiem ar pretiekaisuma īpašībām. Vaccinium ģints ogas pazīstamas ar augstu bioloģisko aktivitāti un labvēlīgu ietekmi uz cilvēku veselību, pateicoties augstam polifenolu saturam. Šobrīd ogu izspiedas tiek pētītas kā alternatīvs fitoķīmisko savienojumu avots ar veselību veicinošu potenciālu. Darba mērķis ir izpētīt piecu Vaccinium spp. ogu izspiedu ekstraktu pretiekaisuma īpašības, izmantojot lipoksigenāzes (5-LOX), ciklooksigenāzes (COX-1) un ksantīna oksidāzes inhibitoru skrīninga testus. Melleņu, krūmmelleņu, lielogu dzērveņu, purva dzērveņu un brūkleņu ekstrakti no koncentrācijas atkarīgā veidā inhibēja 5-LOX, COX-1 un ksantīna oksidāzes aktivitāti. Konstatēta arī sakarība starp inhibējošo efektu un ekstraktu kopējo polifenolu un antocianīnu saturu. Iegūtie rezultāti liecina, ka ogu izspiedu ekstraktiem ir in vitro pretiekaisuma īpašības.

year	journal	country	edition	language
2020-01-01

https://dspace.lu.lv/dspace/handle/7/52089

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