Dicarbonylchloro(pentabenzylcyclopentadienyl)ruthenium as Racemization Catalyst in the Dynamic Kinetic Resolution of Secondary Alcohols

6533b871fe1ef96bd12d0e15

RESEARCH PRODUCT

Dicarbonylchloro(pentabenzylcyclopentadienyl)ruthenium as Racemization Catalyst in the Dynamic Kinetic Resolution of Secondary Alcohols

Mari Päiviö Liisa T. Kanerva Denys Mavrynsky Katri Lundell Reijo Sillanpää Reko Leino

subject

biology Chemistry Organic Chemistry chemistry.chemical_element Alcohol biology.organism_classification Enzyme catalysis Ruthenium Catalysis Kinetic resolution chemistry.chemical_compound Transition metal Organic chemistry Candida antarctica Physical and Theoretical Chemistry Racemization

description

Dicarbonylchloro(pentabenzylcyclopentadienyl)ruthenium has been prepared and its structure confirmed by X-ray analysis. This complex shows excellent catalytic activity and modest stability against air in racemization reactions of secondary alcohols. In Candida antarctica lipase B (CAL-B) catalyzed dynamic kinetic resolution (DKR) of 1-phenyl- and 1-(furan-2-yl)ethanol compounds, the new complex shows improved performance as an alcohol racemization catalyst in comparison with its well-known pentaphenylcyclopentadienyl analogue, hitherto considered as the leading catalyst candidate. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)

year	journal	country	edition	language
2009-03-01	European Journal of Organic Chemistry

https://doi.org/10.1002/ejoc.200801248

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