6533b871fe1ef96bd12d0f8a
RESEARCH PRODUCT
Synthesis of bodinieric acids A and B, both C-18 and C-19-functionalized abietane diterpenoids: DFT study of the key aldol reaction
Ramón J. ZaragozáMiguel A. González-cardenetesubject
Steric effects010405 organic chemistryStereochemistryGeneral Chemical EngineeringGeneral Chemistry010402 general chemistry01 natural sciences0104 chemical scienceschemistry.chemical_compoundchemistryAldol reactionHydrogen–deuterium exchangeAbietic acidAbietanedescription
[EN] The first synthesis of C-18- and C-19-bifunctionalized abietane diterpenoids, bodinieric (or callicapoic) acids, via an aldol reaction has been developed. This key aldol reaction was very sensitive to steric hindrance. This fact has been studied by deuterium exchange experiments and DFT methods. Optimization of this reaction led to the synthesis of anti-inflammatory bodinieric acids A and B, starting from abietic acid
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-01-01 |