6533b871fe1ef96bd12d100c
RESEARCH PRODUCT
In vivo ozone exposure does not increase DNA single-strand breaks in human peripheral lymphocytes
Hc SchröderC FinkenwirthB RoßbachA Muttraysubject
DNA single strandOzoneDNA damageHealth Toxicology and MutagenesisDNA Single-StrandedParallel studyGeneral MedicineBiologyToxicologyMolecular biologyPeripheralchemistry.chemical_compoundOzonechemistryIn vivoImmunologyHumansLymphocytesOzone exposureDNADNA Damagedescription
In this randomized parallel study, we examined whether an acute ozone (O3) exposure leads to increased DNA strand breaks in human lymphocytes. The groups were exposed to 0.21 ppm O3 or filtered air for two hours. 30min and 4.5 h after exposure, DNA damage was determined in isolated lymphocytes using the Fast Micromethod. There was no detectable effect after O3 exposure. We conclude that an acute O3 exposure at the tested concentration does not lead to persistent DNA damage.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2013-08-10 | Human & Experimental Toxicology |