6533b871fe1ef96bd12d10bc

RESEARCH PRODUCT

Changes of energy metabolism, myosin light chain composition, lactate dehydrogenase isozyme pattern and fibre type distribution of denervated fast-twitch muscle from rabbit after low frequency stimulation

Heinz ReichmannW. A. Nix

subject

Myosin light-chain kinaseChemical PhenomenaPhysiologyClinical BiochemistryStimulationMyosinschemistry.chemical_compoundPhysiology (medical)Lactate dehydrogenaseMyosinAnimalsDenervationMuscle DenervationLagomorphaL-Lactate DehydrogenasebiologyHistocytochemistryChemistryMusclesSuccinate dehydrogenasebiology.organism_classificationElectric StimulationMuscle DenervationIsoenzymesChemistrybiology.proteinBiophysicsRabbitsEnergy Metabolism

description

The influence of low frequency (8-10 Hz) electrical stimulation on denervated fast-twitch muscle from rabbit was investigated. Prolonged direct stimulation of denervated muscle resulted in higher oxidative enzyme activities. Furthermore, single fibre analyses for succinate dehydrogenase showed a more uniform distribution of activity in stimulated-denervated muscle when compared to normal muscle. As was also the case following stimulation of innervated muscle, glycolytic enzymes were decreased in activity and the LDH-isozyme pattern was also shifted towards heart type. No change of the myosin light chain pattern could be observed after 56 days of stimulation.

yearjournalcountryeditionlanguage
1985-10-01Pfl�gers Archiv European Journal of Physiology
https://doi.org/10.1007/bf00582568