Latgales reģionā cirkulējošo Mycobacterium tuberculosis genotipu raksturojums

6533b871fe1ef96bd12d13fb

RESEARCH PRODUCT

Latgales reģionā cirkulējošo Mycobacterium tuberculosis genotipu raksturojums

Beatrise Jerina

subject

spoligotipēšana IS6110 RFLP genotips Mycobacterium tuberculosis Bioloģija

description

Tuberkuloze ir pasaulē izplatīta infekcijas slimība, kuras izraisītājas ir M. tuberculosis kompleksā ietilpstošās mikobaktērijas. Darbs tika veikts, lai noteiktu un raksturotu Latgales reģionā cirkulējošo M. tuberculosis genotipus. Darbā ir izmantotas molekulāras genotipēšanas metodes: starpfragmentu oligonukleotīdu genotipēšanas metode, kas ir balstīta uz polimerāzes ķēdes reakciju un tiešā atkārtojuma (DR) reģiona amplificēšanu; restrikcijas fragmentu garuma polimorfisma analīzes metode, kur M. tuberculosis genotips tiek noteikts pēc insercijas sekvenču IS6110 kopiju skaita un izvietojuma atšķirībām hromosomā. Rezultātos tiek atspoguļots, kādas līnijas un apakšlīnijas atrastas Latgales reģionā, kā arī salīdzināti iegūtie spoligotipi ar Latvijas un kaimiņvalstu populācijā identificētim.

year	journal	country	edition	language
2019-01-01

https://dspace.lu.lv/dspace/handle/7/48250

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