6533b871fe1ef96bd12d15fa
RESEARCH PRODUCT
The 5' Untranslated Region of the
Desai Prashant RLengeler KlausKapitan MarioJanßen Silas MatthiasAlepuz PaulaJacobsen Ilse DErnst Joachim Fsubject
Molecular Biology and PhysiologyDNA Mutational AnalysisEFG1Hyphaehyphal morphogenesisGene Expressiontranslationposttranscriptional regulationDNA-Binding ProteinsFungal Proteinsfilamentation5′ UTRGenes ReporterPolyribosomesProtein BiosynthesisCandida albicansMorphogenesisHumans5' Untranslated RegionsTranscription FactorsResearch Articledescription
Many of the virulence traits that make Candida albicans an important human fungal pathogen are regulated on a transcriptional level. Here, we report an important regulatory contribution of translation, which is exerted by the extensive 5′ untranslated regulatory sequence (5′ UTR) of the transcript for the protein Efg1, which determines growth, metabolism, and filamentation in the fungus. The presence of the 5′ UTR is required for efficient translation of Efg1, to promote filamentation. Because transcripts for many relevant regulators contain extensive 5′ UTR sequences, it appears that the virulence of C. albicans depends on the combination of transcriptional and translational regulatory mechanisms.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-07-07 | mSphere |