6533b871fe1ef96bd12d1830
RESEARCH PRODUCT
Calorimetric and viscosimetric investigation of the interaction between α,β-polyasparthydrazide and sodium dodecyl sulfate micelles
Giovanna PitarresiGennara CavallaroGaetano GiammonaV. Turco LiveriM. L. Turco Liverisubject
Binding abilitychemistry.chemical_compoundChromatographyAqueous solutionPulmonary surfactantchemistryPolymer chemistryPharmaceutical ScienceCalorimetrySodium dodecyl sulfateMicelleDosage formMacromoleculedescription
Abstract The interaction between α,β-polyasparthydrazide (PAHy) and sodium dodecyl sulfate (SDS) micelles in aqueous solution was investigated by calorimetry and viscosimetry. The dependence of the enthalpic effect due to this interaction upon the surfactant concentration was rationalized in terms of a progressive binding of SDS micelles to the polymeric backbone. The analysis of the calorimetric data allow evaluation of the binding ability of SDS micelles to the polymeric chain. The viscosimetric behavior of SDS plus PAHy aqueous solutions, discussed in terms of the parameter F [F = ηrel(PAHy) + ηrel(PAHy) − ηrel(SDS+PAHy)], confirms the occurence of the interaction between SDS micelles and the PAHy macromolecule.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1993-10-01 | International Journal of Pharmaceutics |