A non-catalyzed ring-opening aminolysis reaction of sesquiterpene lactones

6533b871fe1ef96bd12d185b

RESEARCH PRODUCT

A non-catalyzed ring-opening aminolysis reaction of sesquiterpene lactones

C. L. Garcia Begoña García Gonzalo Blay Luz Cardona José R. Pedro

subject

chemistry.chemical_classification Bicyclic molecule Organic Chemistry Sesquiterpene Ring (chemistry)Biochemistry Chloride Pyrrolidine chemistry.chemical_compound Aminolysis chemistry Drug Discovery medicine Organic chemistry Enone Lactone medicine.drug

description

Abstract Santonin (1) and other sesquiterpene lactones (6–10) react cleanly with pyrrolidine at room temperature to afford γ-hydroxyalkylamides, which by elimination with mesyl chloride in pyridine-benzene at 80°C give unsaturated alkylamides.

year	journal	country	edition	language
1994-01-01	Tetrahedron Letters

https://doi.org/10.1016/s0040-4039(00)76003-5

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