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RESEARCH PRODUCT
Computer-aided diagnosis system for characterizing ISUP grade≥2 prostate cancers at multiparametric MRI: A cross-vendor evaluation.
Luc CormierR. De RozarioR. De RozarioC. Gonindard-melodelimaOlivier RouvièreOlivier RouvièreS. TransinM. Funes De La VegaPaul WalkerRomaric LoffroyRémi Souchonsubject
MaleStandardsmedicine.medical_specialtyComputer-assisted diagnosis[SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imagingmedicine.medical_treatmentDiagnostic accuracy[SDV.IB.MN]Life Sciences [q-bio]/Bioengineering/Nuclear medicineSensitivity and Specificity[SDV.IB.MN] Life Sciences [q-bio]/Bioengineering/Nuclear medicine030218 nuclear medicine & medical imaging03 medical and health sciences0302 clinical medicineProstateDiagnosisValidationImage Interpretation Computer-AssistedmedicineHumansRadiology Nuclear Medicine and imagingMagnetic resonance imaging (MRI)Diagnosis Computer-AssistedMultiparametric Magnetic Resonance ImagingAgedRetrospective StudiesProstatectomyPeripheral zoneRadiological and Ultrasound TechnologyReceiver operating characteristicbusiness.industryProstatectomyPI-RADS V2Multiparametric MRIProstatic NeoplasmsGeneral MedicineConfidence interval3. Good health[SDV.IB.IMA] Life Sciences [q-bio]/Bioengineering/Imagingmedicine.anatomical_structureComputer-aided diagnosis030220 oncology & carcinogenesisCohortImagesRadiologybusinessdescription
International audience; Purpose: To assess the performance of a computer-aided diagnosis (CADx) system trained at characterizing International Society of Urological Pathology (ISUP) grade >= 2 peripheral zone (PZ) prostate cancers on multiparametric magnetic resonance imaging (mpMRI) examinations from a different institution and acquired on different scanners than those used for the training database.Patients and methods: Preoperative mpMRIs of 74 men (median age, 65.7 years) treated by prostatectomy between 2014 and 2017 were retrospectively selected. One radiologist outlined suspicious lesions and scored them using Prostate Imaging-Reporting and Data System version 2 (PI-RADSv2); their CADx score was calculated using a classifier trained on an independent database of 106 patients treated by prostatectomy in another institution. The lesions' nature was assessed by comparison with prostatectomy whole-mounts. Diagnostic accuracy was estimated with areas under receiver operating characteristic curves (AUCs). Sensitivity and specificity were calculated using a CADx threshold (>= 0.21) that yielded 95% sensitivity in the training database, and a PI-RADSv2 >= 3 threshold.Results: A total of 127 lesions (PZ, n = 104; transition zone [TZ], n = 23) were described. In PZ, CADx and PI-RADSv2 scores had similar AUCs for characterizing ISUP grade >= 2 cancers (0.78 [95% confidence interval (CI): 0.69-0.87] vs. 0.74 [95%CI: 0.62-0.82], respectively) (P = 0.59). Sensitivity and specificity were respectively 89% (95%CI: 82-97%) and 42% (95%CI: 26-58%) for the CADx score, and 97% (95%CI: 93-100%) and 37% (95%CI: 22-52%) for the PI-RADSv2 score. In TZ, both scores showed poor specificity.Conclusion: In this external cohort, the CADx and PI-RADSv2 scores showed similar performances in characterizing ISUP grade >= 2 cancers. (C) 2019 Societe francaise de radiologie. Published by Elsevier Masson SAS. All rights reserved.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2019-12-01 | Diagnostic and interventional imaging |