6533b871fe1ef96bd12d1b48
RESEARCH PRODUCT
Centenarians as a model to discover genetic and epigenetic signatures of healthy ageing.
Francesco VillaCalogero CarusoGiulia AccardiChiara Carmela SpinelliAnnibale Alessandro Pucasubject
Ageing; Diet; Epigenetics; Genetics; Longevity; Stochasticity; Aging; Developmental Biology0301 basic medicineMaleAgingmedia_common.quotation_subjectLongevityBiologyModels BiologicalEpigenesis Genetic03 medical and health sciencesGeneticGeneticsHumansEpigeneticsmedia_commonStochasticitySettore MED/04 - Patologia GeneraleGeneticsAged 80 and overGenetic variantsLongevityEpigeneticDietAgeing030104 developmental biologyAgeingEvolutionary biologyDevelopmental plasticityChromatin modificationSuccessful ageingEpigeneticsFemaleHealthy ageingDevelopmental Biologydescription
Abstract Centenarians are a model of successful ageing. The data favours the theory that, in order to live to 100, it is mandatory to inherit the right genetic variants from parents or acquire epigenetic variants through the environment. Therefore, the study of epigenetic signatures of healthy ageing is becoming an important aspect to identify the role of chromatin modification in ageing and understand how manage this fine-tuning system. So, according to the concept of developmental plasticity, establishment of a longevity phenotype requires a combination of stochastic and non-stochastic events that modulate the genetic substrate and leads to a different outcome. It can be concluded that centenarians have a more powerful “engine” shaped by evolution, and that the environment, through epigenetic system, is a component influencing outcome.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-09-01 | Mechanisms of ageing and development |