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RESEARCH PRODUCT
Catalysis Concepts in Medicinal Inorganic Chemistry
Alessio TerenziLuca SalassaLuca SalassaSilvia Alonso-de CastroJuan Gurruchaga-peredasubject
antiproliferationChemistry PharmaceuticalInorganic chemistryAntineoplastic Agents010402 general chemistry01 natural sciencesCatalysisCatalysisCatalysibioinorganic chemistryAntineoplastic AgentCoordination ComplexesInorganic ChemicalHumansProdrugsmetallodrugInorganic ChemicalphotochemistryCoordination Complexe010405 organic chemistryChemistryOrganic ChemistryGeneral Chemistry0104 chemical sciencesInorganic ChemicalsSettore CHIM/03 - Chimica Generale E InorganicaBioorthogonal chemistryprodrugHumandescription
Catalysis has strongly emerged in the field of medicinal inorganic chemistry as a suitable tool to deliver new drug candidates and to overcome drawbacks associated to metallodrugs. In this Concept article, we discuss representative examples of how catalysis has been applied in combination with metal complexes to deliver new therapy approaches. In particular, we explain key achievements in the design of catalytic metallodrugs that damage biomolecular targets and in the development of metal catalysis schemes for the activation of exogenous organic prodrugs. Moreover, we discuss our recent discoveries on the flavin-mediated bioorthogonal catalytic activation of metal-based prodrugs; a new catalysis strategy in which metal complexes are unconventionally employed as substrates rather than catalysts.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-12-21 |