6533b871fe1ef96bd12d1c14
RESEARCH PRODUCT
Novel Terphenyls and 3,5-Diaryl Isoxazole Derivatives Endowed with Growth Supporting and Antiapoptotic Properties
Stefania GrimaudoGiuseppina GrisoliaAntonietta Di CristinaDaniele SimoniRiccardo RondaninMarco EleopraMichele RizziMaria Rosaria Pipitone Maria Rita BongiornoRiccardo BaruchelloManlio TolomeoMario AricoFrancesco Paolo Invidiatasubject
chemistry.chemical_classificationMolecular StructureStereochemistryNitro compoundApoptosisBiological activityIsoxazolesChemical synthesisAntiapoptotic AgentStructure-Activity Relationshipchemistry.chemical_compoundchemistryCell Line TumorTerphenyl CompoundsTerphenylDrug DiscoveryNitroHumansMolecular MedicineMoietyIsoxazoledescription
A new study on terphenyl and diaryl-isoxazole and -isoxazoline derivatives, maintaining a common 3-adamantyl-4-hydroxyphenyl moiety, has been conducted to find compounds with growth supporting and antiapoptotic properties. Unexpectedly, diphenyisoxazole derivatives bearing a nitro group replacing the carboxylic function have been found with the highest cell protective activity within the series, in complete and in serum-free conditions. Inhibition of apoptosis induced by daunorubicin has also been observed for the most active compound.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2008-01-01 |