Potential application of polycaprolactone in three-dimensional bioprinting and biomedicine

6533b871fe1ef96bd12d1e45

RESEARCH PRODUCT

Potential application of polycaprolactone in three-dimensional bioprinting and biomedicine

Beatrise Lūcija Rupaine

subject

hidrogēli hondrocīti skrimšļaudu inženierija trīsdimensionālā biodrukāšana Bioloģija polikaprolaktons

description

Darba mērķis bija dažādas arhitektūras polikaprolaktona (PCL) audu pamatņu un dažādu biogēlu biosaderības sākotnējā izpēte, audzējot tajos hondrocītu un osteosarkomas šūnu līnijas skrimšļaudu inženierijas pētniecībai. Novērtējot priekšizpētes rezultātus, konstatēts, ka izvēlētā 3D drukātā audu pamatņu arhitektūra un PCL materiāls ir izmantojams turpmākajiem audu inženierijas pētījumiem. Pētījumā bija paredzēts pārbaudīt biosaderību PCL audu pamatnēm ar dažādiem hidrogēliem, izmantojot šūnu dzīvotspējas testu, iekaisuma reakcijas mediatoru sekrēciju pārbaudi, kā arī ārpusšūnas matriksa veidošanos, kultivējot šūnas 3D audu pamatnē. Šo darba daļu neizdevās īstenot sakarā ar PSKUS darbības ierobežošanu, nosakot ārkārtējo situāciju Valstī sakarā ar Covid-19 pandēmiju. Darbā iegūtie rezultāti tiks izmantoti jauna pētījuma pieteikuma sagatavošanā. Par iegūtajiem rezultātiem ziņots Latvijas Universitātes 77. starptautiskajā zinātniskajā medicīnas konferencē 2019. gada 22. februārī, kā arī iesniegtas tēzes Latvijas Universitātes 78. starptautiskajai zinātniskajai medicīnas konferencei, kas bija paredzēta 2020. gada 20. martā.

year	journal	country	edition	language
2020-01-01

https://dspace.lu.lv/dspace/handle/7/50724

PEPhysical Sciences and Engineering
- PE2Fundamental Constituents of Matter
  - PE2_1Theory of fundamental interactions
  - PE2_2 Phenomenology of fundamental interactions
  - PE2_3Experimental particle physics with accelerators
  - PE2_4Experimental particle physics without accelerators
  - PE2_6Nuclear, hadron and heavy ion physics
  - PE2_8Gas and plasma physics
  - PE2_5Classical and quantum physics of gravitational interactions
  - PE2_7Nuclear and particle astrophysics
  - PE2_9 Electromagnetism
  - PE2_10Atomic, molecular physics
  - PE2_11Ultra-cold atoms and molecules
  - PE2_18Equilibrium and non-equilibrium statistical mechanics: steady states and dynamics
  - PE2_14Lasers, ultra-short lasers and laser physics
  - PE2_17Metrology and measurement
  - PE2_16Non-linear physics
  - PE2_12Optics, non-linear optics and nano-optics
  - PE2_13Quantum optics and quantum information
  - PE2_15Thermodynamics
- PE1Mathematics
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  - PE1_6Geometry and global analysis
  - PE1_8Analysis
  - PE1_7Topology
  - PE1_9Operator algebras and functional analysis
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  - PE1_11Theoretical aspects of partial differential equations
  - PE1_13Probability
  - PE1_14Mathematical statistics
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  - PE1_19Scientific computing and data processing
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  - PE3_3Transport properties of condensed matter
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LSLife Sciences
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  - LS1_5Lipid biology
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  - LS1_11Chemical biology
  - LS1_12Protein design
  - LS1_13Early translational research and drug design
  - LS1_14Innovative methods and modelling in molecular, structural and synthetic biology
  - LS1_10Synthetic biology
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- LS2Integrative Biology: from Genes and Genomes to Systems
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  - LS2_8Proteomics
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  - LS2_12Biostatistics
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  - LS2_13Systems biology
  - LS2_15Integrative biology for personalised medicine
- LS4Physiology in Health, Disease and Ageing
  - LS4_1Organ and tissue physiology and pathophysiology
  - LS4_4Endocrinology
  - LS4_3Physiology of ageing
  - LS4_2Comparative physiology
  - LS4_5Non-hormonal mechanisms of inter-organ and tissue communication
  - LS4_6Microbiome and host physiology
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  - LS4_8Impact of stress (including environmental stress) on physiology
  - LS4_9Metabolism and metabolic disorders, including diabetes and obesity
  - LS4_10The cardiovascular system and cardiovascular diseases
  - LS4_11Haematopoiesis and blood diseases
  - LS4_12Cancer
  - LS4_13Other non-communicable diseases (except disorders of the nervous system and immunity-related diseases)
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  - LS3_5Cell signalling and signal transduction, exosome biology
  - LS3_6Organelle biology and trafficking
  - LS3_7Mechanobiology of cells, tissues and organs
  - LS3_8Embryogenesis, pattern formation, morphogenesis
  - LS3_9Cell differentiation, formation of tissues and organs
  - LS3_10Developmental genetics
  - LS3_11Evolution of developmental strategies
  - LS3_12Organoids
  - LS3_3Cell behaviour, including control of cell shape, cell migration
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  - LS3_14Regeneration
  - LS3_15Development of cell-based therapeutic approaches for tissue regeneration
  - LS3_17Theoretical modelling in cellular, developmental and regenerative biology
  - LS3_16Functional imaging of cells and tissues
  - LS3_1Cell cycle, cell division and growth
  - LS3_2Cell senescence, cell death, autophagy, cell ageing
- LS5Neuroscience and Disorders of the Nervous System
  - LS5_1Neuronal cells
  - LS5_3Neural development and related disorders
  - LS5_5Neural networks and plasticity
  - LS5_10Ageing of the nervous system
  - LS5_11Neurological and neurodegenerative disorders
  - LS5_12Mental disorders
  - LS5_7Sensory systems, sensation and perception, including pain
  - LS5_13Nervous system injuries and trauma, stroke
  - LS5_14Repair and regeneration of the nervous system
  - LS5_15Neuroimmunology, neuroinflammation
  - LS5_16Systems and computational neuroscience (e.g. modelling, simulation, brain oscillations, connectomics)
  - LS5_18Innovative methods and tools for neuroscience
  - LS5_17Imaging in neuroscience
  - LS5_9Neural basis of cognition (e.g. learning, memory, attention, emotions, speech)
  - LS5_6Neurovascular biology and blood-brain barrier
  - LS5_8Neural basis of behaviour (e.g. sleep, consciousness, addiction)
  - LS5_4Neural stem cells
  - LS5_2Glial cells and neuronal-glial communication
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  - LS6_1Innate immunity
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  - LS9_6Marine biotechnology and bioengineering
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SHSocial Sciences and Humanities
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