6533b871fe1ef96bd12d208d

RESEARCH PRODUCT

Approche nutritionnelle de la thérapie du syndrome de l'œil sec : prévention par les acides gras polyinsaturés

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Dry eye disease affects 15% of the population over the age of 65. It is characterized mainly by inflammation of the ocular surface (tear film, conjunctiva and cornea) which represents a relevant target for therapeutic strategies. The side effects and long-term intolerance of anti-inflammatory drugs give rise to an increasing interest for dietary components exhibiting anti-inflammatory properties, such as polyunsaturated fatty acids (PUFAs). In these studies, we developed a scopolamine-induced dry eye model in the rat that mimics changes occurring in Humans suffering from moderate dry eye. We described the time course of clinical signs, inflammation and mucin production loss. We investigated in this model the impact of dietary PUFAs, towards two preventive approaches. In an interventional study, we first evaluated the efficacy of a 2-month supplementation of dietary ω6 and/or ω3 PUFAs in improving the clinical signs and inflammatory markers of dry eye. In an observational study, we secondly evaluated the impact of dietary ω3 PUFA deficiency on the severity of the pathology