6533b871fe1ef96bd12d240e

RESEARCH PRODUCT

Mucoadhesive PEGylated inulin-based self-assembling nanoparticles: In vitro and ex vivo transcorneal permeation enhancement of corticosteroids

Fabio Salvatore PalumboGiovanna PitarresiGaetano GiammonaMariano LicciardiFlavia BongiovìGiulia Di Prima

subject

Polyethylene glycolInulin Self-assembling nanoparticles Transcorneal delivery Retinoic acid Polyethylene glycolTranscorneal deliveryInulinInulinSelf-assembling nanoparticlesPharmaceutical ScienceNanoparticle02 engineering and technologyPenetration (firestop)Permeation021001 nanoscience & nanotechnology030226 pharmacology & pharmacy03 medical and health scienceschemistry.chemical_compound0302 clinical medicinechemistrySettore CHIM/09 - Farmaceutico Tecnologico ApplicativoDrug deliveryAmphiphilePEG ratioRetinoic acidMucoadhesionBiophysics0210 nano-technology

description

Abstract As transcorneal drug delivery is still a challenge, the scope of the present study was to prepare useful nanosystems able to enhance transcorneal permeation/penetration of drugs. Moreover, this work aims to evaluate the effectiveness of inulin-based nanosystems in the specific field of ocular drug delivery and the effect of PEG chains to promote mucoadhesion, stability and transcorneal penetration/permeation enhancer effect of self-assembling nanoparticles in vitro (transwell systems and HCE) and ex vivo (Franz cells and bovine cornea). In particular, inulin was chosen as the starting natural polysaccharide polymer to design a novel amphiphilic derivative named INU-EDA-RA-PEG capable of self-assembling to form self-assembling nanoparticles and corticosteroids-loaded self-assembling nanoparticles. As observed, self-assembling nanoparticles show appropriate particle size values, mucoadhesivity and cytocompatibility. Moreover, self-assembling nanoparticles are able to act efficiently as permeation/penetration enhancer. Additionally, the presence of PEG has positive influence. Thus, the developed inulin-based nanosystems represent a promising tool to improve transcorneal delivery of corticosteroids.

yearjournalcountryeditionlanguage
2019-02-01Journal of Drug Delivery Science and Technology
https://doi.org/10.1016/j.jddst.2018.10.028