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RESEARCH PRODUCT
"Sweet Chemistry": a Green Way for Obtaining Selenium Nanoparticles Active against Cancer Cells
Gerardo Cebrián-torrejónPio ColepicoloAna Maria Da Costa FerreiraErika Mattos SteinDaniel Xavier AndreguettiAntonio Doménech-carbóAdriana Pires Vieirasubject
Chemistrygreen chemistryInorganic chemistrychemistry.chemical_element02 engineering and technologyGeneral ChemistryD-fructose010402 general chemistry021001 nanoscience & nanotechnology01 natural sciences0104 chemical sciencesDynamic light scatteringTransmission electron microscopyInductively coupled plasma atomic emission spectroscopyselenium nanoparticlesZeta potentialcancer cellscytotoxicityCyclic voltammetryInductively coupled plasma0210 nano-technologyHigh-resolution transmission electron microscopySeleniumdescription
We present an environment friendly synthesis of selenium nanoparticles and the study of their cytotoxic activity against uterine sarcoma cancer and fibroblasts cells. Amorphous selenium (a-SeNPs) and trigonal selenium (t-SeNPs) were synthesized using D-fructose as the reducing agent and characterized by high-resolution transmission electron microscopy (HRTEM), energy-dispersive X-ray spectroscopy (EDX), powder X-ray diffraction analysis (XRD), inductively coupled plasma optical emission spectrometry (ICP OES), dynamic light scattering (DLS) to obtain zeta potential values and cyclic voltammetry (CV). Particularly, a-SeNPs presented high toxicity toward the resistant cancer cell line MES-SA/Dx5 and its parental MES-SA line. However, they are not toxic against P4 fibroblast cells in comparative studies.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-10-01 |