Ogļskābes anhidrāzes XII izoformas strukturālie pētījumi

6533b871fe1ef96bd12d288b

RESEARCH PRODUCT

Ogļskābes anhidrāzes XII izoformas strukturālie pētījumi

Elviss Bērtulis

subject

CA XII rentgenstaru kristalogrāfija ogļskābes anhidrāzes hCA Bioloģija proteīnu kristalizācija

description

Ogļskābes anhidrāzes katalizē dzīvajos organismos būtisko bikarbonāta un ogļskābās gāzes savstarpējo atgriezenisko reakciju. Cilvēka organismā ir vairākas ogļskābes anhidrāžu izoformas, un dažu izoformu katalītiskā darbība ir nevēlama. Viena no šīm izoformām, ogļskābes anhidrāzes XII izoforma, saistīta ar vairāku ļaundabīgu audzēju attīstību. Maģistra darba iztrādē tika vairākkārtīgi uzlabota ogļskābes anhidrāzes XII izoformas ekspresijas un attīrīšanas sistēma un iegūtas vairākas ar ligandu saistītas ogļskābes anhidrāzes XII izoformas struktūras. Ar proteīnu rentgenstaru kristalogrāfijas palīdzību tika identificētas dažādu inhibitoru konformācijas ogļskābes anhidrāzes XII izoformas aktīvajā centrā, nodrošinot potenciālas iestrādnes selektīvi inhibējošu ligandu izveidei.

year	journal	country	edition	language
2017-01-01

https://dspace.lu.lv/dspace/handle/7/36213

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