6533b872fe1ef96bd12d2f0e

RESEARCH PRODUCT

Implementation of the Frailty Index in hospitalized older patients: Results from the REPOSI register

Cesari MatteoFranchi CarlottaCortesi LauraNobili AlessandroArdoino Ilaria Pier Mannuccio MannucciTettamanti MauroPasina LucaPerticone FrancescoSalerno FrancescoCorrao SalvatoreMarengoni AlessandraLicata GiuseppeVioli Francesco Gino Roberto Corazza Tarek Kamal Eldin Maria Pia Donatella Di BlancaLanzo GiovannaAstuto SarahDomenico PriscoSilvestri ElenaCenci CaterinaEmmi GiacomoBiolo GianniGuarnieri GianfrancoZanetti MichelaFernandes GiovanniChiuch MassimilianoVanoli MassimoGrignani GiuliaCasella Gianluca Edoardo Alessandro PulixiBernardi Mauro Silvia Li BassiSanti LucaZaccherini GiacomoElmo MannarinoGraziana LupattelliVanessa BianconiFrancesco PaciulloNuti RanuccioValenti RobertoRuvio MartinaCappelli SilviaPalazzuoli AlbertoSalvatore Teresa Ferdinando Carlo SassoGirelli DomenicoOliviero OlivieriMatteazzi ThomasBarbagallo MarioPlances LidiaAlcamo RobertaCalvo LuigiValenti MariaZoli MarcoArnò Raffaella Franco Laghi Pasini Pier Leopoldo CapecchiBicchi MaurizioPalasciano Giuseppe Maria Ester ModeoPeragine MariaPappagallo FabrizioPugliese Stefania Carla Di GennaroPostiglione Alfredo Maria Rosaria Barbella Francesco De StefanoMaria Domenica CappelliniFabio GiovannaSeghezzi Sonia Margherita Migone De AmicisMancarella MartaMari Daniela Paolo Dionigi RossiDamanti Sarah Barbara Brignolo OttoliniBonini GiuliaMiceli Emanuela Marco Vincenzo LentiPadula DonatellaMurialdo GiovanniMarra AlessioCattaneo Federico Maria Beatrice SecchiGhelfi DavideAnastasio LuigiSofia LuciaLuigi Maria CarboneDavì Giovanni Maria Teresa GuagnanoSestili SimonaMancuso GerardoCalipari DanielaBartone Mosè Maria Rachele Meroni Paolo Cavallo PerinLorenzati BartolomeoGruden GabriellaBruno GraziellaAmione CristinaFornengo PaoloTassara RodolfoMelis DeborahRebella LaraDelitala GiuseppePretti Vincenzo Maristella Salvatora MasalaPes ChiaraBolondi LuigiRasciti LeonardoSerio Ilaria Filippo Rossi FanelliAmoroso AntonioMolfino AlessioPetrillo EnricoZuccalà GiuseppeFranceschi Francesco Guido De MarcoChiara CordischiMarta SabbatiniD'aurizio GabriellaRomanelli GiuseppeAmolini ClaudiaChiesa DeborahPicardi Antonio Umberto Vespasiani GentilucciGallo PaoloAnnoni GiorgioCorsi MaurizioZazzetta SaraBellelli GiuseppeSzabo HajnalkaArturi FrancoSuccurro ElenaRubino MariangelaSesti GiorgioLoria Paola Maria Angela BecchiMartucci GianfrancoFantuzzi AlessandraMaurantonio Mauro Maria Grazia Serra Maria Antonietta BleveGasbarrone Laura Maria Rosaria SajevaBrucato AntonioGhidoni Silvia Paola Di CoratoGiancarlo AgnelliEmanuela MarchesiniFabris FabrizioCarlon MichelaTuratto FrancescaBaritusso AldoTuratto FrancescaAmabile AnnalisaOmenetto ElisabettaScarinzi PaoloManfredini RobertoMolino ChristianPala MarcoFabbian FabioBoari Benedetta Alfredo De GiorgiPaolisso Giuseppe Maria Rosaria Rizzo Maria Teresa LaietaRini GiovanbattistaMansueto PasqualePepe IleniaBorghi ClaudioStrocchi Enrico Valeria De SandoPareo IlariaSabbà Carlo Francesco Saverio VellaSuppressa PatriziaValerio RaffaellaAgosti PasqualeFontana FlaviaLoparco FrancescaPugliese StefaniaCapobianco CaterinaFenoglio LuigiBracco Christian Alessia Valentina GiraudoTesta ElisaSerraino CristinaFargion SilviaBonara PaolaPeriti GiuliaPorzio MariannaTiraboschi SliviaPeyvandi FloraTedeschi AlbertoRossio RaffaellaMonzani ValterSavojardo ValeriaFolli ChristianMagnini MariaConca AlessioGobbo GiuliaConca AlessioPallini GiadaValenti MiriamCarlo L. BalduiniBertolino GiampieraProvini StellaQuaglia FedericaDallegri FrancoOttonello LucianoLiberale Luca Wu Sheng ChinCarassale LauraCaporotundo SilviaTraisci Giancarlo Lucrezia De Feudis Silvia Di Carlo Nicola Lucio LiberatoBuratti AlbertoTognin Tiziana Giovanni Battista BianchiGiaquinto SabrinaPurrello Francesco Antonino Di PinoPiro SalvatoreRozzini RenzoFalanga LinaSpazzini ElenaMontrucchio GiuseppeGreco ElisabettaTizzani PietroPetitti PaoloPerciccante AntonioCoralli AlessiaSalmi RaffaellaGaudenzi PiergiorgioGamberini SusannaSemplicini AndreaGottardo LuciaVendemiale GianluigiServiddio GaetanoForlano RobertaMasala CesareMammarella AntonioRaparelli ValeriaBasili StefaniaPerri LudovicaLandolfi RaffaeleMontalto MassimoMirijello AntonioVallone CarlaBellusci MartinoSetti DonatellaPedrazzoli FilippoGuasti LuiginaCastiglioni LuanaMaresca AndreaSquizzato AlessandroMolaro MartaMarco BertolottiMussi Chiara Maria Vittoria LibbraAndrea Di MiceliElisa PellegriniCarulli LuciaVeltri FrancescaSciacqua AngelaQuero MicheleBagnato ChiaraColangelo LidiaFalbo Tania Roberto De GiorgioMauro Dalla SerraGrasso ValentinaRuggeri EugenioIlaria BenzoniSalvi AndreaRoberto LeonardiGrassini ChiaraMascherona IleniaGiorgio MinelliMaltese FrancescaDamiani GiampaoloCapeci WilliamMassimo Mattioli Giuseppe Pio MartinoLorenzo BiondiOrmas MonicaPettinari PietroRomiti RobertoMessina SilviaCavallaro FedericaGhio RiccardiFavorini Serena Anna Dal ColMinisola SalvatoreColangelo LucianoAfeltra AntonellaAlemanno PamelaMarigliano Benedetta Maria Elena PipitaCastellino PietroBlanco JulienZanoli LucaMarco Natale CattaneoFracasso PaolaMaria Valentina AmorusoSaracco ValterFogliati MarisaBussolino CarloDurante VittorioEusebi GiovannaTirotta DanielaMete FrancescaGino MiriamCittadini AntonioVigorito CarloArcopinto MicheleSalzano AndreaBobbio Emanuele Alberto Maria MarraSirico DomenicoMoreo GuidoScopelliti FrancescoGasparini FrancescaCocca MelissaBallestrero AlbertoFerrando FabioBerra SergioDassi Simonetta Maria Cristina NavaGraziella BrunoGhidoni SilviaAmione CristinaBaldassarre StefanoFragapani SalvatoreGruden GabriellaGalanti GiorgioMascherini GabrielePetri CristianStefani LauraGirino MargheritaPiccinelli ValeriaNasso FrancescoGioffrè VincenzaPasquale MariaScattolin GiuseppeMartinelli SergioTurrin MauroSechi LeonardoCatena CristinaColussi Gianluca Ramirez Duque Nieves Muela Molinero Alberto Abad Requejo Pedro Lopez Pelaez VanessaLara Tamargo Corbella Viros XavierFrancesc Formiga Diez Manglano Jesus Bejarano Tello Esperanza Del Corral Behamonte Esther Sevil Puras MariaRomero Manuel Pinilla Llorente Blanca Lopez Gonzalez-cobos CristinaVillalba Garcia M. VictoriaSaez LopezBosco Juan Sanz Baena Susana Arroyo Gallego Marta Gonzalez Becerra Concepcion Fernandez Moyano Antonio Mercedes Gomez Hernandez Manuel Poyato Borrego Pacheco Cuadros Raquel Perez Rojas Florencia Garcia Olid Beatriz Carrascosa Garcia Sara Gonzalez-cruz Cervellera Alfonso Peinado Martinez Marta Sara Carrascosa Garcia Ruiz Cantero Alberto Albarracín Arraigosa Antonio Godoy Guerrero Montserrat Barón Ramos Miguel ÁNgel Machin Jose Manuel Novo Veleiro Ignacio Alvela Suarez LucíaAlfonso Lopez Rubal Bran David Iñiguez Vazquez Iria Rios Prego Monica

subject

GerontologyMaleMultivariate analysisFrailty; Internal medicine and geriatric wards; Multimorbidity; Physical and cognitive impairment; Internal MedicinePhysical and cognitive impairmentPsychological interventionPredictive Value of TestSeverity of Illness Index0302 clinical medicineInternal medicine and geriatric wardsInterquartile rangeFrailty Internal medicine and geriatric wards Multimorbidity Physical and cognitive impairment80 and overMedicine030212 general & internal medicineProspective StudiesHospital MortalityProspective cohort studyMultivariate AnalysiAged 80 and overFrailtyPrognosisFrailty; Internal medicine and geriatric wards; Multimorbidity; Physical and cognitive impairment; Aged; Aged 80 and over; Female; Frailty; Geriatric Assessment; Hospitalization; Humans; Italy; Male; Multimorbidity; Multivariate Analysis; Predictive Value of Tests; Prognosis; Prospective Studies; Regression Analysis; Survival Analysis; Frail Elderly; Hospital Mortality; Severity of Illness IndexHospitalizationItalyPredictive value of testsRegression AnalysisFemaleSurvival AnalysiCohort studyHumanPrognosiFrail ElderlyFrailty; Internal medicine and geriatric wards; Multimorbidity; Physical and cognitive impairment; Aged; Aged 80 and over; Female; Frailty; Geriatric Assessment; Hospitalization; Humans; Italy; Male; Multimorbidity; Multivariate Analysis; Predictive Value of Tests; Prognosis; Prospective Studies; Regression Analysis; Survival Analysis; Frail Elderly; Hospital Mortality; Severity of Illness Index; Internal MedicineSocio-culturaleRegression Analysi03 medical and health sciencesPredictive Value of TestsSeverity of illnessInternal MedicineHumansGeriatric AssessmentSurvival analysisAgedbusiness.industryMultimorbiditySurvival AnalysisInternal medicine and geriatric wardProspective StudieMultivariate Analysisbusiness030217 neurology & neurosurgery

description

Abstract Background Frailty is a state of increased vulnerability to stressors, associated to poor health outcomes. The aim of this study was to design and introduce a Frailty Index (FI; according to the age-related accumulation of deficit model) in a large cohort of hospitalized older persons, in order to benefit from its capacity to comprehensively weight the risk profile of the individual. Methods Patients aged 65 and older enrolled in the REPOSI register from 2010 to 2016 were considered in the present analyses. Variables recorded at the hospital admission (including socio-demographic, physical, cognitive, functional and clinical factors) were used to compute the FI. The prognostic impact of the FI on in-hospital and 12-month mortality was assessed. Results Among the 4488 patients of the REPOSI register, 3847 were considered eligible for a 34-item FI computation. The median FI in the sample was 0.27 (interquartile range 0.21–0.37). The FI was significantly predictive of both in-hospital (OR 1.61, 95%CI 1.38–1.87) and overall (HR 1.46, 95%CI 1.32–1.62) mortality, also after adjustment for age and sex. Conclusions The FI confirms its strong predictive value for negative outcomes. Its implementation in cohort studies (including those conducted in the hospital setting) may provide useful information for better weighting the complexity of the older person and accordingly design personalized interventions.

yearjournalcountryeditionlanguage
2018-01-01
10.1016/j.ejim.2018.06.001http://hdl.handle.net/10447/401645