6533b872fe1ef96bd12d3015

RESEARCH PRODUCT

Influence of Surface Charge and Polymer Coating on Internalization and Biodistribution of Polyethylene Glycol-Modified Iron Oxide Nanoparticles

David VandrouxLaure DumontLionel MauriziAnne-laure PapaNadine MillotFrédéric BouyerPaul Walker

subject

BiodistributionMaterials scienceCell SurvivalStatic ElectricityBiomedical EngineeringPharmaceutical ScienceMedicine (miscellaneous)NanoparticleBioengineeringNanotechnology02 engineering and technologyPolyethylene glycolMRI (Magnetic Resonance Imaging)engineering.material010402 general chemistry01 natural sciencesNanocapsulesCell LinePolyethylene GlycolsMiceStructure-Activity Relationshipchemistry.chemical_compoundCoated Materials BiocompatibleNanocapsulesIn Vivo AssaysCoatingMaterials TestingPEG ratioAnimalsHumansTissue DistributionGeneral Materials ScienceSurface chargeParticle Size[SPI.NANO]Engineering Sciences [physics]/Micro and nanotechnologies/MicroelectronicsMagnetite NanoparticlesMacrophagesSurface GraftingDextransHep G2 Cells021001 nanoscience & nanotechnology0104 chemical scienceschemistryChemical engineeringOrgan SpecificityengineeringNanoparticles0210 nano-technologyIron oxide nanoparticles

description

International audience; The aim of this study was to investigate the influence of the surface charge and coating of Superparamagnetic Iron Oxide Nanoparticles (SPIONs) on their in vitro and in vivo behaviors. Neutral and negatively-charged PEG-based SPIONs were synthesized and compared to Resovist (R), a carboxydextran-based SPION currently used in clinics. Their cytotoxicity, cell internalization, and potential as contrast agents for magnetic resonance imaging were assessed. Neutral pegylated SPIONs were internalized less readily by the reticuloendothelial system and showed a lower uptake by the liver, compared to negatively-charged SPIONs (with carboxydextran and PEG). These results suggested that the charge of functionalized SPIONs was more relevant for their biological interactions than the nature of their coating.

yearjournalcountryeditionlanguage
2015-08-25Journal of Biomedical Nanotechnology
https://doi.org/10.1166/jbn.2015.1996