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RESEARCH PRODUCT
Extracorporeal Shock Wave Stimulates Angiogenesis and Collagen Production in Facial Soft Tissue.
Diana HeimesTalal AlnassarWanting NiuMyron SpectorPeer W. KämmererAbdulmonem AlshihriAbdulmonem AlshihriAbdulmonem Alshihrisubject
MalePathologymedicine.medical_specialtyAngiogenesisSurgical WoundNeovascularization PhysiologicSurgical FlapsMicrocirculationHigh-Energy Shock Waves03 medical and health sciences0302 clinical medicineVascularityMedicineAnimalsHumansSkinWound Healingintegumentary systembusiness.industryGoatsSoft tissueHistologyExtracorporeal shock waveDisease Models Animal030220 oncology & carcinogenesisFaceModels AnimalImmunohistochemistryTissue healing030211 gastroenterology & hepatologySurgeryCollagenmedicine.symptombusinessdescription
Abstract Background This study investigated the efficacy of extracorporeal shock wave (ESW) application in stimulating dermal thickness, vascularity, and collagen synthesis of facial skin in a large animal model. Materials and methods The facial skin of the maxillary and mandibular areas of goats (n = 6 per group) was treated with ESWs of different intensities (0.15 and 0.45 mJ/mm2; 1000 pulses). After 4 d, histology and immunohistochemistry were used to evaluate the following: dermal thickness, total number and abundance of microvessels, amount of type 1 collagen, and α-smooth muscle actin expression. Results Dermal thickness, number and abundance of microvessels, and collagen synthesis increased after ESW application at both intensities (each P Conclusions A single-session application of focused low-energy ESWs to facial skin can increase dermal thickness by stimulating collagen production and local microcirculation. These findings commend the technique for future investigation for pretreatment of local or microvascular skin flaps to enhance tissue healing.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2019-01-07 | The Journal of surgical research |