6533b872fe1ef96bd12d30bb
RESEARCH PRODUCT
On the purinergic system in rat duodenum : existence of P1and P2receptors on the smooth muscle
A. PostorinoRosa SerioFlavia Mulèsubject
medicine.medical_specialtyContraction (grammar)DuodenumPhysiologyMuscle RelaxationIn Vitro TechniquesBiologydigestive systemBiochemistryAdenosine TriphosphateTheophyllineInternal medicinemedicineAnimalsTheophyllineReceptorGuanethidinePurinergic receptorReceptors PurinergicMuscle SmoothElectric StimulationRatsAtropineElectrophysiologymedicine.anatomical_structureEndocrinologyDuodenummedicine.drugdescription
In rat duodenum, in vitro, in the presence of atropine and guanethidine, ATP administration caused a tetrodotoxin-insensitive relaxation followed by a rebound contraction. A similar response was obtained also after electrical field stimulation (EFS) of non-adrenergic, non-cholinergic (NANC) nerves. alpha, beta-methylene-TP and theophylline antagonized the response to ATP, but they failed to affect the noradrenaline- and EFS-induced relaxation. These results suggest that P1 and P2 receptors are present in rat duodenum, but their activation is not responsible for the inhibitor effects due to the NANC nerves.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1990-03-01 | Archives Internationales de Physiologie et de Biochimie |