Išēmiska insulta ietekme uz smadzeņu angioģenēzi un neiroģenēzi eksperimentālā vidējās cerebrālās artērijas oklūzijas modelī

6533b872fe1ef96bd12d334a

RESEARCH PRODUCT

Išēmiska insulta ietekme uz smadzeņu angioģenēzi un neiroģenēzi eksperimentālā vidējās cerebrālās artērijas oklūzijas modelī

Vladislava Kurtukova

subject

angioģenēze Farmācija fMCAo cerebrāls infarkts neiroģenēze

description

Insults ir viens no biežākajiem mirstības un invaliditātes cēloņiem pasaulē. Išēmisks insults jeb cerebrāls infarkts (CI) ir sastopamākais insulta veids. CI agrīnās stadijās bojājuma skartajā smadzeņu puslodē ir stimulēta angioģenēze un neiroģenēze, tomēr trūkst datu par to, kā mainās šo procesu norise ilgtermiņā pēc CI. Šī pētījuma mērķis bija noskaidrot, kā mainās angioģenēzes un neiroģenēzes biomarķieru (VEGF, DCX, NeuN) ekspresija 2 mēnešus pēc CI inducēšanas, izmantojot eksperimentālo vidējās cerebrālās oklūzijas modeli. Darbā iegūtie rezultāti liecina, ka 2 mēnešus pēc CI inducēšanas peļu smadzeņu garozā ir samazināta angiogēnā aktivitāte, kā arī ir samazināts neiroblastu skaits neirogēnajās zonās. Savukārt išēmijas skartajā zonā corpus striatum neiroģenēze ir pastiprināta, tomēr tā nespēj atjaunot neironu tīklu pēc išēmiska bojājuma.

year	journal	country	edition	language
2021-01-01

https://dspace.lu.lv/dspace/handle/7/54710

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