6533b872fe1ef96bd12d36eb
RESEARCH PRODUCT
In vivo imaging and quantification of the continuous keratin filament network turnover
Reinhard WindofferReinhard WindofferThomas WürflingerTil AachStefan WöllAnne KölschRudolf E. Leubesubject
chemistry.chemical_classificationCell typeKeratin Filamentintegumentary systemCell divisionCell migrationmacromolecular substancesBiologyCell biologychemistryKeratinCytoskeletonIntermediate filamentPreclinical imagingdescription
Keratin polypeptides are major components of the epithelial cytoskeleton forming a filamentous 3D-network. Like intermediate filament polypeptides of other cell types, keratins make up a stable, but elastic network that is responsible for mechanical stress resilience. At the same time the keratin network is able to change its shape during development, cell division, metastasis and cell migration.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2008-08-30 |