6533b872fe1ef96bd12d36f5
RESEARCH PRODUCT
The astrocyte LAMP lights a T cell TRAIL of death
Ari WaismanLisa Johannsubject
0301 basic medicineEffectorGeneral NeuroscienceT cellCentral nervous systemBiologyCell biology03 medical and health sciences030104 developmental biology0302 clinical medicinemedicine.anatomical_structureApoptosismedicine030217 neurology & neurosurgeryAstrocytedescription
In a recent issue of Nature, Sanmarco et al. reveal a novel mechanism by which astrocytes maintain an anti-inflammatory state in the central nervous system (CNS). IFNγ released by gut-licensed meningeal NK cells was found to induce TRAIL expression on astrocytes, causing effector T cell apoptosis.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-05-01 | Neuron |