6533b872fe1ef96bd12d3783
RESEARCH PRODUCT
Macromolecules in ordered media III. A fluorescence study on the association of poly-2-vinylpyridine with a phospholipid bilayer
Clara M. GómezIolanda PorcarAgustín CamposRosa GarcíaVicente Soriasubject
Partition coefficientchemistry.chemical_classificationActivity coefficientChemistryIonic strengthVesicleAnalytical chemistryPhysical chemistryPolymerLipid bilayerEffective nuclear chargeMacromoleculedescription
Association of low molecular weight poly-2-vinylpyridine taken as a polycation model with unilamellar vesicles based on dimirystoylphosphatidic acid has been experimentally investigated by means of fluorescence energy transfer experiments. The conventional profiles for the binding isotherms were obtained, confirming strong deviations from the ideality of these complex fluid composites. Two approaches, named binding and partitioning equilibrium, respectively, were used to obtain the association constant, K A; the number of phospholipids that form a binding site, N; the partition coefficient, Λ; the activity coefficient, γ; and the effective charge, v. Analysis of these parameters as a function of polymer concentration and ionic strength was carried out.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2007-12-10 |