Cilvēka bokavīrusa iesaiste dziļāko elpceļu slimību un akūta gastroenterīta patoģenēzē hospitalizētiem bērniem

6533b872fe1ef96bd12d3d3e

RESEARCH PRODUCT

Cilvēka bokavīrusa iesaiste dziļāko elpceļu slimību un akūta gastroenterīta patoģenēzē hospitalizētiem bērniem

subject

bērni dziļāko elpceļu slimības akūts gastroenterīts Bioloģija HBoV1-3

description

Dziļāko elpceļu slimības un akūts gastroenterīts ir galevnais cēlonis bērnu saslimšanai un mirstībai visā pasaulē. Arī Latvijas bērnu populācijā šīs slimības ir bieži sastopamas, tomēr ne vienmēr ir zināms šo slimību etioloģiskais aģents. Cilvēka bokavīruss (HBoV) ir 2005. gadā atklāts parvovīruss, ko saista ar elpceļu slimību un akūta gastroenterīta izraisīšanu bērniem. Šī pētījuma mērķis bija noskaidrot HBoV iesaisti dziļāko elpceļu slimību un akūta gastroenterīta patoģenēzē hospitalizētiem bērniem. Šajā pētījumā 46,03% bērnu ar dziļāko elpceļu slimībām un 16,67% bērnu ar akūtu gastroenterītu detektēta HBoV genoma sekvences klātbūtne organismā. Sekvencējot noteikts, ka pacientiem ar dziļāko elpceļu slimībām sastopams HBoV1, savukārt pacientiem ar akūtu gastroenterītu – HBoV2 un HBoV3. Akūta HBoV1 infekcija konstatēta 13 bērniem ar dziļāko elpceļu slimībām. Secinājums: Bērniem ar dziļāko elpceļu slimībām konstatē HBoV1 genoma sekvences klātbūtni organismā, bet pacientiem ar gastroenterītu – HBoV2 un HBoV3. Atsevišķos gadījumos HBoV1 izraisa smagas elpceļu slimības bērniem, savukārt HBoV2 un HBoV3 iesiaste gastroenterīta etiopatoģenēzē nav pierādīta. Atslēgvārdi: HBoV1-3, dziļāko elpceļu slimības, akūts gastroenterīts, bērni.

year	journal	country	edition	language
2016-01-01

https://dspace.lu.lv/dspace/handle/7/32211

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