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RESEARCH PRODUCT

Bacteriochlorin-diketopyrrolopyrrole (DPP) hybrids : New near-infrared fluorophores for biosensing/bioimaging applications

subject

description

Near-infrared (700-900 nm) absorbing and emitting organic-based fluorophores are valuable tools for bioimaging applications. Indeed, biological component absorption, diffusion and autofluorescence are quite low in this region (known as the first therapeutic window NIR-I), making tissues relatively transparent to these long wavelengths. Bacteriochlorins are porphyrins derivatives in which two double bonds are reduced. These molecules display a strong absorption and emission within NIR-I spectral range. DPPs are structurally simpler fluorophores displaying very interesting properties. They have high fluorescence quantum yields, are highly (photo)chemically and thermally stable. The aim of this thesis is to associate these two fluorophore units in order to yield novel multi-chromophoric molecular architectures that combine their complementary properties. DPP dyes used in the design of the hybrids are highly versatile. They can be used as fluorogenic reporters for the detection of relevant enzymatic activities in the biological media by introducing a specific triggering unit of the targeted analyte and water-solubilizing moieties.