6533b872fe1ef96bd12d40f8

RESEARCH PRODUCT

Synthesis and characterization of nanoparticles with an iron oxide magnetic core and a biologically active trialkylsilylated aliphatic alkanolamine shell

Dmitry ZablotskyIrina ShestakovaAlla ZablotskayaIzolda SegalEdmunds LukevicsAnatoly MishnevIlona DomrachevaMikhail Maiorov

subject

Iron oxideNanoparticleCondensed Matter PhysicsSilaneElectronic Optical and Magnetic Materialschemistry.chemical_compoundchemistryMonolayerMagnetic nanoparticlesAlkanolamineMethiodidehuman activitiesMagnetiteNuclear chemistry

description

Water-soluble double-coated magnetic nanoparticles (NPs) containing cytotoxic decyldimethyl(β-dimethylaminoethoxy)silane methiodide (AA) molecule sorbed at biocompatible magnetic particles, which consist of magnetite pre-coated with oleic acid (OA), have been prepared. X-ray line profile broadening analysis was used for crystallite size determination. The method of magnetogranulometry has been used for determination of diameter of iron oxide magnetic core and magnetic properties of NPs prepared. In vitro cytotoxicity on monolayer tumor cell lines HT-1080 (human fibrosarcoma), MG-22A (mouse hepatoma) and normal mouse fibroblasts (NIH 3T3) has been studied. It was revealed that all the water-based colloidal solutions obtained are non-toxic and possess high NO-induction ability.

yearjournalcountryeditionlanguage
2007-04-01Journal of Magnetism and Magnetic Materials
https://doi.org/10.1016/j.jmmm.2006.11.176