6533b872fe1ef96bd12d4305

RESEARCH PRODUCT

Gold( i )–BODIPY–imidazole bimetallic complexes as new potential anti-inflammatory and anticancer trackable agents

Michel PicquetBenoît BertrandChristine GozePierre Le GendrePhilippe RichardEwen BodioAudrey TrommenschlagerSouheila AmorAli BettaiebAli BettaiebFlorian ChotardCatherine PaulCatherine PaulLucile DondaineLucile DondaineLucile Dondaine

subject

Boron Compoundsmedicine.drug_classStereochemistryAnti-Inflammatory AgentsAntineoplastic Agents[SDV.CAN]Life Sciences [q-bio]/Cancer010402 general chemistry01 natural sciences[ CHIM ] Chemical SciencesAnti-inflammatorylaw.invention[ SDV.CAN ] Life Sciences [q-bio]/CancerInorganic Chemistrychemistry.chemical_compoundConfocal microscopylawCoordination ComplexesCell Line TumorDrug DiscoverymedicineImidazoleHumans[CHIM]Chemical SciencesBimetallic stripCell ProliferationFluorescent Dyes010405 organic chemistryChemistryDrug discoveryImidazolesIn vitro0104 chemical sciences3. Good healthGoldBODIPY

description

International audience; Two new gold(I)–BODIPY–imidazole based trackable therapeutic bimetallic complexes have been synthesized and fully characterized. They display strong antiproliferative properties on several types of cancers including colon, breast, and prostate and one of them presents a significant anti-inflammatory effect. Additionally, the two compounds could be visualised in vitro by confocal microscopy in the submicromolar range.

10.1039/c7dt01377ahttps://hal-univ-bourgogne.archives-ouvertes.fr/hal-01563252