6533b873fe1ef96bd12d4b45

RESEARCH PRODUCT

Polyketides and nitrogenous metabolites from the endophytic fungus Phomopsis sp. D15a2a

Werner E.g. MüllerSimon-patrick HöfertZhen LiuChristoph JaniakPeter ProkschMariam MoussaHaiqian YuBo UmeokoliBo UmeokoliHao-fu Dai

subject

biologyTetrapeptide010405 organic chemistryStereochemistryOrganic ChemistryEndophytic fungus010402 general chemistrybiology.organism_classification01 natural sciencesBiochemistry0104 chemical scienceschemistry.chemical_compoundchemistryAmideDrug DiscoveryPhomopsis sp.Alternanthera bettzickianaTwo-dimensional nuclear magnetic resonance spectroscopyDerivative (chemistry)

description

Abstract Three new polyketides, phomopones A−C (1–3), one new cyclic tetrapeptide, 18-hydroxydihydrotentoxin (4), and a new amide, 6-hydroxyenamidin (5) together with a known derivative, enamindin (6) were obtained from the endophytic fungus Phomopsis sp. D15a2a isolated from the plant Alternanthera bettzickiana. The structures of the new compounds were elucidated by 1D, 2D NMR and HRMS data. The absolute configurations of the isolated metabolites were determined either by X-ray crystallography, Marfey’s method or by converting the compounds to Mosher esters.

yearjournalcountryeditionlanguage
2019-12-01Tetrahedron Letters
https://doi.org/10.1016/j.tetlet.2019.151325