6533b873fe1ef96bd12d4e85
RESEARCH PRODUCT
Definition of discrete signals involved in human T-cell activation
U. MoebiusE. SchiedhelmM. HauerK H Meyer Zum BüschenfeldeM. SchykowskiK. DeuschS. Meuersubject
Adultmedicine.drug_classT-LymphocytesT cellImmunologyReceptors Antigen T-CellAntigen-Presenting CellsStimulationBiologyLymphocyte ActivationMonoclonal antibodyMonocytesmedicineHumansReceptorMolecular Biologychemistry.chemical_classificationAntibodies MonoclonalCell biologySignallingmedicine.anatomical_structurechemistryAlternative complement pathwayInterleukin-2GlycoproteinInterleukin-1description
Abstract Mitogenic activities of monoclonal antibodies directed at denned receptor structures expressed on the surface of mature human T lymphocytes were employed to study, in detail, signals involved in primary T-cell activation. Based on differential requirements for stimulation, two discrete pathways of human T-cell activation can be defined: the antigen-induced mode of activation initiated through the Ti-T3 antigen-receptor complex and an alternative pathway which can be triggered by monoclonal antibodies directed at the T11 glycoprotein. Perhaps more importantly, the approach taken here allows the definition of stable intermediate cellular stages within the activation cascade and, thus, to analyze the signalling capabilities of individual receptor molecules.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1986-11-01 | Molecular Immunology |