Synthesis of N-acyl Derivatives of Aminocombretastatin A-4 and Study of their Interaction with Tubulin and Downregulation of c-Myc.

6533b873fe1ef96bd12d572f

RESEARCH PRODUCT

Synthesis of N-acyl Derivatives of Aminocombretastatin A-4 and Study of their Interaction with Tubulin and Downregulation of c-Myc.

J. Alberto Marco Eva Falomir Alberto Pla J. Fernando Díaz Celia Martín-beltrán Fernando Josa-prado Juan Murga Raül Agut Raquel Gil-edo Miguel Carda

subject

Down-Regulation Antineoplastic Agents Microtubule dynamics Structure-Activity Relationship Downregulation and upregulation Microtubule Tubulin Cell Line Tumor Drug Discovery Humans MTT assay Aminocombretastatin A-4 Cell Proliferation biology Chemistry Cell growth In vitro Tubulin Modulators Molecular Docking Simulation Tubulin c-Myc Biochemistry Cell culture Docking (molecular)biology.protein Drug Screening Assays Antitumor Anti-proliferative activity Anti-mitotic

description

11 p.-9 fig.-4 tab.

year	journal	country	edition	language
2021-01-01	Medicinal chemistry (Shariqah (United Arab Emirates))

10.2174/1573406416666201120103913 https://pubmed.ncbi.nlm.nih.gov/33222678

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