6533b873fe1ef96bd12d59c8
RESEARCH PRODUCT
Opioid poorly-responsive cancer pain. Part 3. Clinical strategies to improve opioid responsiveness.
Russell K. PortenoySebastiano Mercadantesubject
Palliative carebusiness.industrymedicine.medical_treatmentCalcium channelAnalgesicPalliative CareDrug ResistanceDrug SynergismBioinformaticsClonidineAnalgesics OpioidAnesthesiology and Pain MedicineOpioidAnesthesiaNeoplasmsNeuropathic painMedicineHumansNeurology (clinical)businessCancer painAdjuvantGeneral Nursingmedicine.drugdescription
Some pain syndromes may be difficult to treat due to a poor response to opioids. This situation demands a range of alternative measures, including the use of adjuvant drugs with independent effects, such as antidepressants, sodium channel-blocking agents, steroids and anti-inflammatory drugs (NSAIDs); drugs that reduce opioid side effects; and drugs that enhance analgesia produced by opioids, such as N-methyl-D-aspartate (NMDA) antagonists, calcium channel antagonists, and clonidine. Other approaches, including opioid trials, neural blockade when necessary, and psychological interventions, also may be useful.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2001-04-01 | Journal of pain and symptom management |