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RESEARCH PRODUCT
Coordinating properties of the Cephalexine antibiotic. A potentiometric study of the complexes formation between Cephalexine and Co(II), Ni(II) and Cu(II) metal ions
Maria-josé MartínezJoaquín BorrásJosé M. MoratalAntonio Donairesubject
Bicyclic moleculeChemistryMetal ions in aqueous solutionPotentiometric titrationInorganic chemistryProtonationIonInorganic ChemistryMetalCrystallographyvisual_artMaterials Chemistryvisual_art.visual_art_mediumSide chainChemical stabilityPhysical and Theoretical Chemistrydescription
Abstract The formation of complexes between Co(II), Ni(II) and Cu(II) with Cephalexine has been investigated using potentiometric techniques. The stability constants of the complexes formed were calculated using the non-linear least-squares computer program SUPERQUAD. The obtained values were: Co(II) logβ1=2.40, logβMLOH=8.89; Ni(II) logβ1=2.80, logβ2=5.10, logβML2OH=12.09; Cu(II) logβ1=4.094 (25 °C, 0.1 M KNO3). The compound [Ni(CEX)(OH2)4]BPh4 has been synthesized and characterized by electronic, IR and NMR spectroscopies as well as by magnetic measurements. From these studies it is proposed that the Cephalexinate anion acts as a bidentate ligand and is bound to the metal ion through the carbonyl and the amino-NH2 groups of the side chain.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1989-08-01 | Inorganica Chimica Acta |