6533b874fe1ef96bd12d601c

RESEARCH PRODUCT

P1296 : Blocking NMDA receptors prolongs survival in rats with acute liver failure by dual protective mechanisms in kidney and brain

C. Gimemez-garzoAna AgustiCarmina MontoliuI. TorregrosaVicente Hernandez-rabazaAmparo UriosVicente FelipoAmparo Ruiz-sauriAndrea Cabrera-pastorAlba González-usanoOmar CauliAlfonso MiguelCarmen Carda

subject

medicine.medical_specialtyCreatinineKidneyMultivariate analysisHepatologyReceiver operating characteristicbusiness.industrySignificant differenceLiver failureDiagnostic accuracyGastroenterologychemistry.chemical_compoundmedicine.anatomical_structurechemistryAnesthesiaInternal medicinemedicineNMDA receptorbusiness

description

were 1094.67±239.37mIU/ml. The difference in values between these groups was statistically significant (p = 0.004). There was a statistically significant difference in total leucocyte count, serum creatinine, INR and cleaved CK18 M30 levels among those that survived vs expired. Multivariate analysis found that all these independently predict mortality. A receiver operating characteristic curve was drawn for the new score. The score found was compared with the King’s College criteria and the MELD score, the new scoring system was found to have higher sensitivity and specificity for mortality compared with other standard prognostic markers in ALF, and has a better diagnostic accuracy (Table 1).

yearjournalcountryeditionlanguage
2015-04-01Journal of Hepatology
https://doi.org/10.1016/s0168-8278(15)30290-7