The Creolophins: A Family of Linear Triquinanes fromCreolophus cirrhatus (Basidiomycete)

6533b874fe1ef96bd12d60ca

RESEARCH PRODUCT

The Creolophins: A Family of Linear Triquinanes fromCreolophus cirrhatus (Basidiomycete)

Friederike Deininger Judith Birnbacher Timm Anke Till Opatz Till Opatz Anja Schüffler Heinz Kolshorn

subject

chemistry.chemical_classification Ketone Stereochemistry Organic Chemistry Alcohol Tumor cells Nuclear magnetic resonance spectroscopy Ring (chemistry)Terpenoid chemistry.chemical_compound chemistry Creolophus cirrhatus Moiety Physical and Theoretical Chemistry

description

Complicatic acid and five novel linear triquinanes were isolated from mycelial cultures of Creolophus cirrhatus. The creolophins A, C, D, and E represent a novel type of highly oxidized triquinane sesquiterpenoids. Whereas those compounds with a secondary alcohol moiety in ring A are stable, the exomethylene ketone creolophin E (5) partly dimerized during workup to form the decacyclic 1,4-dioxepin-6-one neocreolophin (6). Compounds 5 and 6 display cytotoxic activities against several tumor cell lines.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)

year	journal	country	edition	language
2007-11-01	European Journal of Organic Chemistry

https://doi.org/10.1002/ejoc.200700555

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