6533b874fe1ef96bd12d6261

RESEARCH PRODUCT

Gut-microbiota-derived extracellular vesicles: Overlooked mediators in host–helminth interactions?

Javier SotilloCinzia CantacessiGabriel RinaldiAlba Cortés

subject

0301 basic medicineHelminth infectionsHost (biology)030231 tropical medicineHelminthiasisBiologyGut florabiology.organism_classificationdigestive systemExtracellular vesiclesGastrointestinal MicrobiomeHost-Parasite InteractionsCell biologyExtracellular Vesicles03 medical and health sciencesCrosstalk (biology)fluids and secretions030104 developmental biology0302 clinical medicineInfectious DiseasesHelminthsparasitic diseasesAnimalsHumansParasitology

description

Helminth infections impact the composition of the mammalian gut microbiota; however, the mechanisms underpinning these interactions are, thus far, unknown. In this article, we propose that microbiota-derived extracellular vesicles might represent key players in host-helminth-microbiome crosstalk, and outline future directions to elucidate their role(s) in host-parasite relationships.

https://doi.org/10.1016/j.pt.2021.05.009