6533b883fe1ef96bd12dcdee

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Additional file 4 of The Wnt-specific astacin proteinase HAS-7 restricts head organizer formation in Hydra

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Additional file 4: Fig. S2. Phylogenetic tree of astacin metalloproteinases established by PhyLM 3.0 (SEAVIEW package) and based on an alignment of the catalytic domains only, omitting pro-sequences and multiple C-terminal domains. Numbers indicate probability values (in %) obtained from 100 bootstrap replications. Protein abbreviations from bottom: fAST, flavastacin (Flavobacterium meningosepticum, i.e. Chryseobacterium meningosepticum, i.e. Elisabethkingia meningoseptica, Q47899, used as outgroup); HEA-1, Hydractinia echinata astacin-1 (Q2MCX9); HEA-3, H. echinata astacin-3 (Q2MCX7); HEA-4, H. echinata astacin-4 (Q2MCX6); HMP1, Hydra vulgaris metalloproteinase-1 (NP_001296695.1), AST, astacin (Astacus astacus, P07584); ALV, alveolin (Oryzias latipes, Q9IBE7); ZHE-1, zebrafish hatching enzyme-1 (Danio rerio, Q1LW01); HCE-1, high choreolytic enzyme-1 (O. latipes, P31580); zNEP, nephrosin (Danio rerio, A2VD22); cNEP, nephrosin (Cyprinus carpio, O42326); hOVA, ovastacin (H. sapiens, Q6HA08); mOVA, ovastacin (Mus musculus, Q6HA09); TLD, tolloid (Drosophila melanogaster, P25723); TLL1, tolloid-like 1 (H. sapiens, O43897); TLL2, tolloid-like 2 (H. sapiens, Q9Y6L7); BMP1, bone morphogenetic protein-1 (H. sapiens, P13497); NAS-35, nematode astacin-35 (C. elegans, P98060); SPAN, Strongylocentrotus purpuratus astacin (P98068); hMEPβ, meprin β (H. sapiens, Q16820); mMEPβ, meprin β (M. musculus, Q61847); zMEPβ, meprin β (D. rerio, B8JKC0); hMEPα, meprin α (H. sapiens, Q16819), mMEPα, meprin α (M. musculus, P28825); zMEPa1, meprin α1 (D. rerio, Q5RHM1); zMEPα2, meprin α2 (D. rerio, F1QRQ5); HMP2, H. vulgaris metalloproteinase 2, NP_001296695.1); HAS-9, H. vulgaris astacin-9 (XP_002161766.1); HAS-8, H. vulgaris astacin-8 (XP_002153855.1); HAS-10, H. vulgaris astacin-10 (XP_002159980.2); HAS-7, H. vulgaris astacin-7 (XP_012560086.1); HAS-11, H. vulgaris astacin-11 (XP_012561076.1); HAS-1, H. vulgaris astacin-1 (XP_012565441.1); HEA-2, H. echinata astacin-2 (Q2MCX8); PMP1, Podecoryne carnica metalloproteinase-1 (O62558); HAS-4, H. vulgaris astacin-4 (XP_002162738.1); HAS-2, H. vulgaris astacin-2 (XP_002162822.1); HAS-6, H. vulgaris astacin-6 (XP_002157397.2); HAS-5, H. vulgaris astacin-5 (XP_002164800.1); HAS-3, H. vulgaris astacin-3 (XP_002166229.3).