Search results for " (NOS)"

Diminished neurogenic femoral artery vasoconstrictor response in a Zucker obese rat model: differential regulation of NOS and COX derivatives.

2014

Objective: Peripheral arterial disease is one of the macrovascular complications of type 2 diabetes mellitus. This study addresses femoral artery regulation in a prediabetic model of obese Zucker rats (OZR) by examining cross-talk between endothelial and neural factors. Methods and Results: Arterial preparations from lean (LZR) and OZR were subjected to electrical field stimulation (EFS) on basal tone. Nitric oxide synthase (NOS) and cyclooxygenase (COX) isoform expression patterns were determined by immunohistochemical labelling and Western blotting. Results indicate significantly reduced noradrenergic contractions in preparations from OZR compared with those of LZR. Functional inhibition …

Role of tetrahydrobiopterin in pulmonary vascular remodelling associated with pulmonary fibrosis

2013

[Background]: Pulmonary hypertension in idiopathic pulmonary fibrosis (IPF) is indicative of a poor prognosis. Recent evidence suggests that tetrahydrobiopterin (BH4), the cofactor of nitric oxide synthase (NOS), is involved in pulmonary hypertension and that pulmonary artery endothelial-to-mesenchymal transition (EnMT) may contribute to pulmonary fibrosis. However, the role of BH4 in pulmonary remodelling secondary to pulmonary fibrosis is unknown. This study examined the BH4 system in plasma and pulmonary arteries from patients with IPF as well as the antiremodelling and antifibrotic effects of the BH4 precursor sepiapterin in rat bleomycin-induced pulmonary fibrosis and in vitro EnMT mod…

Impairment of nasal mucociliary clearance after radiotherapy for childhood head cancer.

2001

Background Radiotherapy of the head region in children is known to cause long-term sequelae, such as facial, dental, and ocular abnormalities. We investigated whether a decreased nasal mucociliary function occurs after radiotherapy of the head in children. Methods A saccharin/charcoal test was performed in 20 children treated with radiotherapy of the head and in 20 controls, age-matched and gender-matched. Results We found a decreased nasal mucociliary clearance (lower percentage of responses (p = 0083) and longer mucociliary transport times (p = .0001) in the patients compared with the controls. The radiotherapy dosage influenced the response to the test (p = .0046). Conclusions Irradiatio…

Down-regulation of the expression of endothelial NO synthase is likely to contribute to glucocorticoid-mediated hypertension.

1999

Hypertension is a side effect of systemically administered glucocorticoids, but the underlying molecular mechanism remains poorly understood. Ingestion of dexamethasone by rats telemetrically instrumented increased blood pressure progressively over 7 days. Plasma concentrations of Na + and K + and urinary Na + and K + excretion remained constant, excluding a mineralocorticoid-mediated mechanism. Plasma NO 2 − /NO 3 − (the oxidation products of NO) decreased to 40%, and the expression of endothelial NO synthase (NOS III) was found down-regulated in the aorta and several other tissues of glucocorticoid-treated rats. The vasodilator response of resistance arterioles was tested by intravital m…

Quando la mafia trovò l’America

2009

L'articolo si sofferma ad analizzare i processi di reciproca influenza oltreoceano tra Cosa Nostra siciliana e la mafia americana.

Gozos a nuestra Señora del Consuelo, venerada en el Coro del Convento de nuestra Señora de los Angeles, Religiosas Franciscas, de Ruzafa

1750

El full orlat Grav. xil. enmarcat de "Nra. Sra. del Consuelo", flanquejat per ornaments florals Text del goig a tres col. separades per bandes

Mare nostrum: questioni di aggettivo?

2020

Riflessione sull'espressione 'mare nostrum', sulle sue connotazioni geografiche e politiche, sul peso ideologico che il possessivo 'nostrum' ha esercitato sulla tradizione successiva fino ai nostri giorni.

Hellēņu dimensija Eiropai : Rīgas 1. starptautiskās hellēnistikas konferences "Hellēņu pasaule un mēs" materiāli

2003

Le stragi, Cosa nostra e la forbice sociale

2020

Oltre che per la sua soggettività politica, Cosa Nostra si è distinta nel tempo per la sua complessa pervasività sistemica, per la sua capacità di sfruttare le “intersezioni” tra dimensioni criminali e economia legale e per la duttile capacità di adattamento ai “vincoli di contesto” che, via via, le si sono presentati. Per comprenderne, quindi, l’attuale configurazione, occorre partire da tale complessità, senza appiattirne la storia in una “notte nera” dove “tutte le mafie sono uguali”, ma valorizzando le sue dimensioni identitarie, radicate su fatti, eventi e intersezioni assolutamente unici. Limitando l’attenzione all’ultimo trentennio, punto di osservazione privilegiato sono le stragi d…

«QUESTO MARE CI INGANNA»: IL MEDITERRANEO, IL MARE DEI ROMANI

2021

Questo mare ci inganna»: The Mediterranean, the sea of the Romans · Is the Mediterranean really the mare nostrum? What is the meaning of the expression mare nostrum? This paper tries to answer these questions, opening up another one: is the Mediterranean a s ea with many names or a sea without a name?