Search results for " 16"

Rebolucion del año mil seyscientos cinquenta, y vno / Compuesta por Don Pedro Mercader, y Caspe ..

1651

Grav. xil. a port. Sig.: A6

Oral microbiome in Proliferative Verrucous Leukoplakia exhibits loss of diversity and enrichment of pathogens.

2021

Abstract Objectives Oral microbiome plays an important role in oral diseases. Among them, proliferative verrucous leucoplakia (PVL) is an uncommon form of progressive multifocal leukoplakia with a worryingly rate of malignant transformation. Here, we aimed to characterize the oral microbiome of PVL patients and compare it with those of healthy controls. Material and methods Oral biopsies from ten PVL patients and five healthy individuals were obtained and used to compare their microbial communities. The sequence of the V3-V4 region of 16S rRNA gene was used as the taxonomic basis to estimate and analyze the composition and diversity of bacterial populations present in the samples. Results O…

Long-range DNA looping and gene expression analyses identify DEXI as an autoimmune disease candidate gene

2011

The chromosome 16p13 region has been associated with several autoimmune diseases, including type 1 diabetes (T1D) and multiple sclerosis (MS). CLEC16A has been reported as the most likely candidate gene in the region, since it contains the most disease-associated single-nucleotide polymorphisms (SNPs), as well as an imunoreceptor tyrosine-based activation motif. However, here we report that intron 19 of CLEC16A, containing the most autoimmune disease-associated SNPs, appears to behave as a regulatory sequence, affecting the expression of a neighbouring gene, DEXI. The CLEC16A alleles that are protective from T1D and MS are associated with increased expression of DEXI, and no other genes in …

Re-expression of C/EBP alpha induces CYP2B6, CYP2C9 and CYP2D6 genes in HepG2 cells.

1998

Cytochrome P450 (CYP) activity is very low or even absent in human hepatomas, a phenomenon that is accompanied by low levels of some liver transcription factors, notably C/EBP alpha. To investigate a possible link between this transcription factor and hepatic CYP expression, we have stably transfected HepG2 cells with a C/EBP alpha vector containing a Zn-inducible metallothionein promoter. Expression of functional C/EBP alpha up to liver levels concomitantly increased the mRNAs of several members of the CYP2 family (2B6, 2C9 and 2D6), suggesting that this transcription factor may play a relevant role in controlling the hepatic expression of CYP enzymes.

Copia veridica, de la grave enfermedad, lamentable muerte y tiernas clausulas del Testamento de ... D. Carlos II ...

Grav. sobre el tít Sign. : [ ]2

Copia de el Testamento cerrado, que en dos de octubre de mil y setecientos, y del codicilo que en cinco del mismo mes, y año hizo ... D. Carlos II ..…

Sign.: A16 Port. orlada i al seu vers amb esc. real grav

Aplausos deuidos al dis seis de nouiembre, natal de Carlos II nuestro Señor y Rey de las Españas.

Fris, caplletra ornada, filets Text a 1 col. - Reclams Sign.: [ ]1, A-C4

Carta, que escriuio la señora Archiduquesa à su querido Esposo Don Carlos, Archiduque de Austria.

Sig. [ ]2 Reclams. - Totes les p. orlades amb bandes, cristus al començament i ornament tip. floral al final

Respuesta canonica, y theologica, al memorial que dio al Rey ... Fr. Francisco Manuel de Zuñiga, Obispo de Ciudad Rodrigo ... del Orden de San Agust…

1696

Sig. [A]-I2 Port. orlada. - Reclams

Algunas reflexiones acerca de la stjue de 9 de julio de 2020 sobre los pactos novatorios en materia de cláusulas suelo

2021

The Sentence of the Court of Justice of the European Union of July 9, 2020 comes to answer the five questions that, in its preliminary question, the Court of First Instance and Instruction No. 3 of Teruel asks about the validity of the new agreements in the context of the floor clauses, establishing jurisprudential doctrine on this matter about which our Supreme Court had previously ruled in its Judgments of October 16, 2017, in the sense of considering the agreed floor clause null as a consequence of the novation agreement and, subsequently, those of April 11, 2018 and September 13, 2018 in the opposite direction, declaring that the novation agreement was valid. It is a long-awaited and in…